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\u0622\u0632\u0645\u0648\u0646 \u062a\u062d\u0631\u06cc\u06a9\u200c\u0632\u0627\u06cc\u06cc (Irritation) \u062f\u0631 \u0632\u06cc\u0633\u062a\u200c\u0633\u0627\u0632\u06af\u0627\u0631\u06cc<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\u0686\u0631\u0627 \u0644\u0627\u0632\u0645 \u0627\u0633\u062a\u061f<\/strong>
\u0637\u0628\u0642 ISO 10993-1:2018<\/strong> \u0647\u0645\u0647\u200c\u06cc \u062f\u0633\u062a\u06af\u0627\u0647\u200c\u0647\u0627\u06cc \u067e\u0632\u0634\u06a9\u06cc (\u0627\u0632 \u062a\u0645\u0627\u0633 \u06a9\u0648\u062a\u0627\u0647 \u062a\u0627 \u0637\u0648\u0644\u0627\u0646\u06cc) \u0628\u0627\u06cc\u062f \u0627\u0632 \u0646\u0638\u0631 \u067e\u062a\u0627\u0646\u0633\u06cc\u0644 \u0627\u06cc\u062c\u0627\u062f \u062a\u062d\u0631\u06cc\u06a9 \u0645\u0648\u0636\u0639\u06cc<\/strong> \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0634\u0648\u0646\u062f \u062a\u0627 \u0627\u0632 \u0628\u0631\u0648\u0632 \u0642\u0631\u0645\u0632\u06cc\u060c \u062a\u0648\u0631\u0645\u060c \u062f\u0631\u062f \u0648 \u0633\u0627\u06cc\u0631 \u0648\u0627\u06a9\u0646\u0634\u200c\u0647\u0627\u06cc \u0646\u0627\u062e\u0648\u0627\u0633\u062a\u0647 \u062c\u0644\u0648\u06af\u06cc\u0631\u06cc \u0634\u0648\u062f.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t
\u06a9\u062f\u0627\u0645 \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u0631\u0627 \u0627\u0631\u062c\u0627\u0639 \u062f\u0647\u06cc\u0645\u061f<\/h6>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u062c\u0627\u0631\u06cc \u0648 \u062a\u0631\u062c\u06cc\u062d\u06cc:<\/strong> ISO 10993-23:2021<\/strong> (\u0622\u0632\u0645\u0648\u0646\u200c\u0647\u0627\u06cc \u062a\u062d\u0631\u06cc\u06a9)<\/p>
\u0648\u0636\u0639\u06cc\u062a ISO 10993-10:<\/strong> \u062a\u0645\u0631\u06a9\u0632 \u0622\u0646 \u0627\u06a9\u0646\u0648\u0646 \u0631\u0648\u06cc \u062d\u0633\u0627\u0633\u06cc\u062a\u200c\u0632\u0627\u06cc\u06cc<\/strong> \u0627\u0633\u062a\u061b \u06af\u0632\u06cc\u0646\u0647\u200c\u0647\u0627\u06cc \u0622\u0632\u0645\u0648\u0646 \u062a\u062d\u0631\u06cc\u06a9 in vivo \u0642\u062f\u06cc\u0645\u06cc \u06a9\u0647 \u062f\u0631 10993-10 \u0628\u0648\u062f\u060c \u062f\u0631 10993-23<\/strong> \u0647\u0645 \u067e\u0648\u0634\u0634 \u062f\u0627\u062f\u0647 \u0634\u062f\u0647\u200c\u0627\u0646\u062f.<\/p>
\u0646\u06a9\u062a\u0647 \u0639\u0645\u0644\u06cc:<\/strong> \u0628\u0631\u0627\u06cc \u0627\u0633\u0646\u0627\u062f \u062f\u0627\u062e\u0644\u06cc \u0648 \u067e\u0631\u0648\u062a\u06a9\u0644\u200c\u0647\u0627\u060c 10993-23<\/strong> \u0631\u0627 \u0645\u0628\u0646\u0627 \u0628\u06af\u0630\u0627\u0631\u06cc\u062f \u0648 \u0641\u0642\u0637 \u062f\u0631 \u0635\u0648\u0631\u062a \u0646\u06cc\u0627\u0632 \u0628\u0647 \u0631\u0648\u0634\u200c\u0647\u0627\u06cc \u062d\u06cc\u0648\u0627\u0646\u06cc\u060c \u0628\u0647 \u0628\u062e\u0634\u200c\u0647\u0627\u06cc \u0645\u0631\u062a\u0628\u0637 10993-23 (in vivo) \u0627\u0631\u062c\u0627\u0639 \u062f\u0647\u06cc\u062f.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t
\u0645\u0633\u06cc\u0631\u0647\u0627\u06cc \u0622\u0632\u0645\u0648\u0646 (\u0628\u0631 \u0627\u0633\u0627\u0633 \u0645\u062d\u0644 \u062a\u0645\u0627\u0633)<\/h6>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\u067e\u0648\u0633\u062a:<\/strong> \u062a\u062d\u0631\u06cc\u06a9 \u067e\u0648\u0633\u062a\u06cc (in vitro \u0628\u0631 \u067e\u0627\u06cc\u0647 RhE \/ in vivo \u062f\u0631 \u0635\u0648\u0631\u062a \u0646\u06cc\u0627\u0632)<\/p>
\u063a\u0634\u0627\u0647\u0627\u06cc \u0645\u062e\u0627\u0637\u06cc:<\/strong> \u062f\u0647\u0627\u0646\u06cc\u060c \u0628\u06cc\u0646\u06cc\u060c \u0648\u0627\u0698\u06cc\u0646\u0627\u0644\u060c \u0631\u06a9\u062a\u0627\u0644\u060c \u0622\u0644\u062a \u062a\u0646\u0627\u0633\u0644\u06cc<\/p>
\u0686\u0634\u0645:<\/strong> \u0622\u0632\u0645\u0648\u0646 \u062a\u062d\u0631\u06cc\u06a9 \u0686\u0634\u0645\u06cc (in vitro \u062a\u0631\u062c\u06cc\u062d\u06cc\u060c \u062f\u0631 \u0645\u0648\u0627\u0631\u062f \u062e\u0627\u0635 in vivo)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t
\u0631\u0648\u06cc\u06a9\u0631\u062f \u0622\u0632\u0645\u0648\u0646\u200c\u0647\u0627 (\u0628\u0647\u200c\u0631\u0648\u0632 \u0628\u0627 10993-23)<\/h6>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\u062a\u0631\u062c\u06cc\u062d \u0628\u0627 \u0627\u0635\u0648\u0644 3R (\u062c\u0627\u06cc\u06af\u0632\u06cc\u0646\u06cc\/\u06a9\u0627\u0647\u0634\/\u0627\u0635\u0644\u0627\u062d):<\/strong>
in vitro (\u062a\u0631\u062c\u06cc\u062d\u06cc):<\/strong> \u0645\u062f\u0644 \u0627\u067e\u06cc\u062f\u0631\u0645 \u0627\u0646\u0633\u0627\u0646\u06cc \u0628\u0627\u0632\u0633\u0627\u062e\u062a\u0647 (RhE) + readout \u0632\u0646\u062f\u0647\u200c\u0645\u0627\u0646\u06cc MTT<\/strong> (18\u201324 h) \u0631\u0648\u06cc \u0639\u0635\u0627\u0631\u0647\u200c\u0647\u0627\u06cc \u0645\u062d\u0635\u0648\u0644<\/strong> \u0645\u0637\u0627\u0628\u0642 ISO 10993-12<\/p>
\u062f\u0631 \u0635\u0648\u0631\u062a \u0646\u06cc\u0627\u0632 \u06cc\u0627 \u0639\u062f\u0645 \u06a9\u0641\u0627\u06cc\u062a in vitro:<\/strong>
in vivo:<\/strong> \u0622\u0632\u0645\u0648\u0646 \u062f\u0627\u062e\u0644\u200c\u062c\u0644\u062f\u06cc\/\u067e\u0648\u0633\u062a\u06cc\/\u0686\u0634\u0645\u06cc \u0637\u0628\u0642 \u0633\u0646\u0627\u0631\u06cc\u0648 \u0648 \u0645\u0627\u062a\u0631\u06cc\u0633 \u062a\u0645\u0627\u0633<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t
\u06af\u0627\u0645\u200c\u0647\u0627\u06cc \u0627\u062c\u0631\u0627\u06cc\u06cc \u067e\u06cc\u0634\u0646\u0647\u0627\u062f\u06cc (SOP \u0641\u0634\u0631\u062f\u0647)<\/h6>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
1-\u062a\u0639\u0631\u06cc\u0641 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0648 \u062a\u0645\u0627\u0633:<\/strong> \u0646\u0648\u0639 \u0628\u0627\u0641\u062a\u060c \u0645\u062f\u062a \u062a\u0645\u0627\u0633\u060c \u0645\u0633\u06cc\u0631 \u0628\u0627\u0644\u06cc\u0646\u06cc<\/p>
2-\u0628\u0631\u0631\u0633\u06cc \u0633\u0648\u0627\u0628\u0642 \u0645\u0627\u062f\u0647\/\u0641\u0631\u0645\u0648\u0644\u0627\u0633\u06cc\u0648\u0646:<\/strong> \u0648\u062c\u0648\u062f \u0634\u0648\u0627\u0647\u062f \u062a\u062d\u0631\u06cc\u06a9\u061f<\/p>
3-\u0622\u0645\u0627\u062f\u0647\u200c\u0633\u0627\u0632\u06cc \u0639\u0635\u0627\u0631\u0647\u200c\u0647\u0627:<\/strong> \u0642\u0637\u0628\u06cc\/\u063a\u06cc\u0631\u0642\u0637\u0628\u06cc \u0637\u0628\u0642 ISO 10993-12<\/strong><\/p>
4-\u0622\u0632\u0645\u0648\u0646 in vitro RhE (\u062a\u0631\u062c\u06cc\u062d\u06cc):<\/strong> \u0627\u0639\u0645\u0627\u0644 \u0639\u0635\u0627\u0631\u0647\u060c \u0627\u0646\u06a9\u0648\u0628\u0627\u0633\u06cc\u0648\u0646\u060c \u0633\u0646\u062c\u0634 MTT\u060c \u0645\u0642\u0627\u06cc\u0633\u0647 \u0628\u0627 \u06a9\u0646\u062a\u0631\u0644\u200c\u0647\u0627<\/p>
5-\u062a\u0635\u0645\u06cc\u0645\u200c\u06af\u06cc\u0631\u06cc:<\/strong><\/p>
\u0642\u0628\u0648\u0644:<\/strong> \u067e\u0627\u0633\u062e \u0632\u06cc\u0631 \u062d\u062f \u0645\u0631\u062c\u0639 \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f<\/p>
\u0627\u0628\u0647\u0627\u0645\/\u062a\u062f\u0627\u062e\u0644\/\u0645\u0627\u062a\u0631\u06cc\u0633 \u067e\u06cc\u0686\u06cc\u062f\u0647:<\/strong> \u062a\u06a9\u0631\u0627\u0631\/\u06a9\u0646\u0641\u0631\u0645\u0627\u062a\u0648\u0631\u06cc \u06cc\u0627 in vivo<\/strong> \u0647\u062f\u0641\u0645\u0646\u062f<\/p>
6-\u06af\u0632\u0627\u0631\u0634 \u06a9\u0627\u0645\u0644:<\/strong> \u0637\u0631\u0627\u062d\u06cc\u060c \u0627\u0633\u062a\u062e\u0631\u0627\u062c\u060c \u062f\u0627\u062f\u0647 \u062e\u0627\u0645\u060c \u0622\u0646\u0627\u0644\u06cc\u0632 \u0622\u0645\u0627\u0631\u06cc\u060c \u0646\u062a\u06cc\u062c\u0647\u200c\u06af\u06cc\u0631\u06cc\u060c \u0631\u062f\u06cc\u0627\u0628\u06cc \u0645\u0648\u0627\u062f<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t
\u067e\u0630\u06cc\u0631\u0634 \u0646\u0638\u0627\u0631\u062a\u06cc (\u062c\u0645\u0639\u200c\u0628\u0646\u062f\u06cc \u06a9\u0627\u0631\u0628\u0631\u062f\u06cc)<\/h6>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
10993-23<\/strong> \u062f\u0631 \u0633\u0637\u062d \u0628\u06cc\u0646\u200c\u0627\u0644\u0645\u0644\u0644\u06cc \u0645\u0631\u062c\u0639 \u0628\u0647\u200c\u0631\u0648\u0632 \u0628\u0631\u0627\u06cc \u062a\u062d\u0631\u06cc\u06a9 \u0627\u0633\u062a \u0648 in vitro<\/strong> \u0631\u0627 \u0631\u0648\u0634 \u0627\u0648\u0644\u06cc\u0647<\/strong> \u0645\u06cc\u200c\u062f\u0627\u0646\u062f.<\/p>
\u0628\u0631\u062e\u06cc \u0645\u0631\u0627\u062c\u0639 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0647\u0646\u0648\u0632 \u0627\u0631\u062c\u0627\u0639\u0627\u062a\u06cc \u0628\u0647 10993-10 \u062f\u0627\u0634\u062a\u0647 \u0628\u0627\u0634\u0646\u062f\u060c \u0627\u0645\u0627 \u0628\u0627 \u0627\u0633\u062a\u0646\u0627\u062f \u0628\u0647 10993-23 \u0648 \u0645\u0646\u0637\u0642 \u0639\u0644\u0645\u06cc 3R\u060c \u0645\u0633\u06cc\u0631 in vitro-first<\/strong> \u0645\u0639\u0645\u0648\u0644\u0627\u064b \u067e\u0630\u06cc\u0631\u0641\u062a\u0646\u06cc \u0627\u0633\u062a. \u0628\u0631\u0627\u06cc \u0627\u0631\u0633\u0627\u0644\u200c\u0647\u0627\u06cc \u062d\u0633\u0627\u0633\u060c \u06cc\u06a9 \u0645\u0646\u0637\u0642 \u0641\u0646\u06cc \u06a9\u0648\u062a\u0627\u0647<\/strong> \u062f\u0631\u0628\u0627\u0631\u0647 \u0627\u0646\u062a\u062e\u0627\u0628 in vitro \u067e\u06cc\u0648\u0633\u062a \u06a9\u0646\u06cc\u062f.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t
\u0686\u0647 \u0632\u0645\u0627\u0646\u06cc \u0633\u0631\u0627\u063a in vivo \u0628\u0631\u0648\u06cc\u0645\u061f<\/h6>\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t
\u062a\u062f\u0627\u062e\u0644 \u0622\u0632\u0645\u0648\u0646 \u0628\u0627 \u0631\u0646\u06af\u200c\u0647\u0627\/\u0627\u0641\u0632\u0648\u062f\u0646\u06cc\u200c\u0647\u0627 \u06cc\u0627 \u0627\u062b\u0631 \u0645\u0627\u062a\u0631\u06cc\u0633<\/strong> \u0631\u0648\u06cc MTT<\/p>
\u0646\u06cc\u0627\u0632 \u0628\u0647 \u0645\u062f\u0644 \u0628\u0627\u0641\u062a\u06cc \u062e\u0627\u0635<\/strong> \u06a9\u0647 RhE \u067e\u0648\u0634\u0634 \u0646\u062f\u0647\u062f<\/p>
\u0627\u0628\u0647\u0627\u0645 \u0627\u06cc\u0645\u0646\u06cc<\/strong> \u0628\u0639\u062f \u0627\u0632 \u062a\u06a9\u0631\u0627\u0631 in vitro \u06cc\u0627 \u0627\u062e\u062a\u0644\u0627\u0641 \u0628\u0627 \u062f\u0627\u062f\u0647\u200c\u0647\u0627\u06cc \u0634\u06cc\u0645\u06cc\u0627\u06cc\u06cc\/\u0628\u0627\u0644\u06cc\u0646\u06cc<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"
\u0622\u0632\u0645\u0648\u0646 \u062a\u062d\u0631\u06cc\u06a9\u200c\u0632\u0627\u06cc\u06cc (Irritation) \u062f\u0631 \u0632\u06cc\u0633\u062a\u200c\u0633\u0627\u0632\u06af\u0627\u0631\u06cc \u0686\u0631\u0627 \u0644\u0627\u0632\u0645 \u0627\u0633\u062a\u061f\u0637\u0628\u0642 ISO 10993-1:2018 \u0647\u0645\u0647\u200c\u06cc \u062f\u0633\u062a\u06af\u0627\u0647\u200c\u0647\u0627\u06cc \u067e\u0632\u0634\u06a9\u06cc (\u0627\u0632 \u062a\u0645\u0627\u0633 \u06a9\u0648\u062a\u0627\u0647 \u062a\u0627 \u0637\u0648\u0644\u0627\u0646\u06cc) \u0628\u0627\u06cc\u062f \u0627\u0632 \u0646\u0638\u0631 \u067e\u062a\u0627\u0646\u0633\u06cc\u0644 \u0627\u06cc\u062c\u0627\u062f \u062a\u062d\u0631\u06cc\u06a9 \u0645\u0648\u0636\u0639\u06cc \u0627\u0631\u0632\u06cc\u0627\u0628\u06cc \u0634\u0648\u0646\u062f \u062a\u0627 \u0627\u0632 \u0628\u0631\u0648\u0632 \u0642\u0631\u0645\u0632\u06cc\u060c \u062a\u0648\u0631\u0645\u060c \u062f\u0631\u062f \u0648 \u0633\u0627\u06cc\u0631 \u0648\u0627\u06a9\u0646\u0634\u200c\u0647\u0627\u06cc \u0646\u0627\u062e\u0648\u0627\u0633\u062a\u0647 \u062c\u0644\u0648\u06af\u06cc\u0631\u06cc \u0634\u0648\u062f. \u06a9\u062f\u0627\u0645 \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u0631\u0627 \u0627\u0631\u062c\u0627\u0639 \u062f\u0647\u06cc\u0645\u061f \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u062c\u0627\u0631\u06cc \u0648 \u062a\u0631\u062c\u06cc\u062d\u06cc: ISO 10993-23:2021 (\u0622\u0632\u0645\u0648\u0646\u200c\u0647\u0627\u06cc \u062a\u062d\u0631\u06cc\u06a9) \u0648\u0636\u0639\u06cc\u062a ISO 10993-10: […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"footnotes":""},"categories":[78],"tags":[],"class_list":["post-16184","post","type-post","status-publish","format-standard","hentry","category-biocompatibility-test"],"_links":{"self":[{"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/posts\/16184","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/comments?post=16184"}],"version-history":[{"count":4,"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/posts\/16184\/revisions"}],"predecessor-version":[{"id":16188,"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/posts\/16184\/revisions\/16188"}],"wp:attachment":[{"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/media?parent=16184"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/categories?post=16184"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/parslab.co\/en\/wp-json\/wp\/v2\/tags?post=16184"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}